Nuclei septales

The septal area (medial olfactory area), consisting of the lateral septum and medial septum, is an area in the lower, posterior part of the medial surface of the frontal lobe, and refers to the nearby septum pellucidum.

The septal nuclei are located in this area.

The septal nuclei are composed of medium-size neurons which are classified into dorsal, ventral, medial, and caudal groups.

The septal nuclei receive reciprocal connections from the olfactory bulb, hippocampus, amygdala, hypothalamus, midbrain, habenula, cingulate gyrus, and thalamus.

The septal nuclei are essential in generating the theta rhythm of the hippocampus.

The septal area (medial olfactory area) has no relation to the sense of smell, but it is considered a pleasure zone in animals. The septal nuclei play a role in reward and reinforcement along with the nucleus accumbens.

In the 1950s, Olds & Milner showed that rats with electrodes implanted in this area will self-stimulate repeatedly (i.e., press a bar to receive electric current that stimulate the neurons).

Experiments on the septal area of humans have taken place since the 1960s.